While we were submitting this manuscript, another study performed with comparable methodology than ours demonstrated a similar resistance to Aldara-induced psoriasis-like dermatitis in K14Cre × Il36rfl/fl (DK14) mice than in Il36r-deficient mice, which corroborates our results (Hernandez-Santana et al, 2020). Here, IL1RL2 is linked to skin disorder.