It has been suggested that there exists three different signaling pathways that mediate three clinical phenotypes of psoriasis in patients: the chronic plaque-type psoriasis mediated by TNF, the pustular psoriasis by IL-36, supported by IL-1, cytokines, and the acute phase psoriasis mediated by type-I interferon (Conrad & Gilliet, 2018). The gene discussed is TNF; the disease is psoriasis.