Primed T cells expressing PD-1 are inactivated by engagement of its ligand programmed death ligand 1 (PD-L1) expressed on tumor cells, thereby promoting tumor growth and metastasis.1 The anti-PD-1 antibody nivolumab was recently approved for previously treated non-small cell lung cancer (NSCLC). Here, CD274 is linked to non-small cell lung carcinoma.