For example, AD is clearly identified by Aβ and tau pathologies present in the immuno-stained tissue, TDP-43 inclusions are identified on TDP-43 immunohistochemistry and may be localized to limbic areas and / or cortical regions, and Lewy body disease is characterized by the presence and distribution of Lewy bodies identified on alpha-synuclein immunostained tissues and can be located in brainstem, limbic, and/or cortical regions [3, 6, 9, 20, 21, 41, 42]. This evidence concerns the gene TARDBP and Alzheimer disease.