TARDBP and early-onset autosomal dominant Alzheimer disease: Examples include: Alzheimer’s Disease (AD), dementia with Lewy bodies (DLB), and frontotemporal degeneration which manifest neuropathologically as beta-amyloid plaques and tau-immunoreactive neurofibrillary tangles (AD), alpha-synuclein-positive Lewy bodies (DLB, pathologically Lewy body disease - LBD), and inclusions positive for TDP-43, tau, or other entities (frontotemporal lobar degeneration of various subtypes) [3].