ESR1 and cancer: Additionally, 16 potential novel ACC drug targets were identified for which there is varying degrees of evidence for drug targeting in other cancers targeting of the genes: CDK4, NOTCH1, NF1, MDM2, EGFR, BRCA1, BRCA2, ATM, BRAF, PTCH1, TSC1, TSC2, KIT, RET, ESR1, EZH2 [65].