Furthermore, increased IFN-γ immunoreactivity, a cytokine important for macrophage activation and induction of major histocompatibility complex (MHC) class II molecule expression on immune cells, is observed in glia and neurons in the ventral horn of the spinal cord in ALS, compared to controls [75], suggesting a sustained activation of the innate immune response. Here, IFNG is linked to amyotrophic lateral sclerosis.