TNF and amyotrophic lateral sclerosis: For example, miR-22-3p, miR-125b-5p, miR-146b-5p, miR-155-5p, miR-214-3p and miR-365-3p are overexpressed in microglia from SOD1G93A mice, and these modulate inflammatory genes linked to ALS, such as the IL-6 pathway which determines the transcription of TNF [205].