Herein, we observed similar results that, NDRG2 overexpression dramatically induced the cell cycle arrest in G1 phase and inhibited cell cycle marker protein cyclin B1 and cyclin A2 expression levels in all the three ovarian cancer cell lines, suggesting that NDRG2 might suppress ovarian cancer cell proliferation via affecting the resetting of cancer cell cycle. The gene discussed is CCNB1; the disease is ovarian cancer.