In CRT candidates without ICM, atrial diameter, non-LBBB, Pro-BNP, Hs-CRP, NYHA class IV are associated with all-cause mortality and HF transplantation, which could provide a readily available tool for identifying patients who require intensive monitoring and for effective prediction of long-term outcomes among NICM patients who are potential recipients of CRT. The gene discussed is CRP; the disease is hydrops fetalis.