This decreases involved key regulators of cell cycle such as cyclins D1, D3, E and their associated cyclin-dependent kinases, Cdk 2, 4, 6 in human of various cancer cells (i.e., prostate, hepatoma, colon, non-small cell lung cancer, epidermoid carcinoma, ovarian cancer, melanoma) [47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62]. This evidence concerns the gene CCND1 and cancer.