HDAC9 and non-small cell lung carcinoma: Indeed, silymarin may cooperate positively with histone deacetylase (HDAC) inhibitors (i.e., trichostatin A), and with DNA methyltransferase inhibitor (i.e., 5′-Aza-deoxycytidine) in upregulating E-cadherin expression together in human non-small cell lung cancer cells to strongly decrease the invasion/migration of these cells [119].