The expression of the EMT/invasion-related genes Snail, interleukin-8 (IL-8) and MMP-3 was described to increase whereas the expression of the non-tumor epithelial markers E-cadherin and Claudin-1 was reduced in PC-3M human prostate carcinoma 1E8 and 2B4 cell lines by ATP-activated P2X7 [105]. This evidence concerns the gene CXCL8 and neoplasm.