It has been shown that introducing TRPV2 into androgen-dependent LNCaP cells enhances cell migration along with expression of invasion markers matrix metalloproteinase (MMP) 9 and cathepsin B. Constitutive activity of TRPV2 showed to mediate the growth and invasive properties of PC3 prostate tumors suggesting that upregulation of this channel is a feature of castration-resistant PCa [99]. Here, TRPV2 is linked to posterior cortical atrophy.