Upregulation of Piezo1 has been associated with increased cytosolic [Ca2+]i, phosphorylation of Akt kinase and mammalian target of rapamycin (mTOR), activation of cyclin dependent kinase 4 (CDK4) and cyclin D1 and cell proliferation/survival in DU145 PCa cells [68]. Here, CDK4 is linked to posterior cortical atrophy.