Because phosphorylation of ZBP1 at Tyr396 by Src family kinases releases β-actin mRNA and elicits translation of β-actin [54], these findings suggest that the netrin receptor DCC (deleted in colorectal cancer) and the BDNF receptor TrkB activate Src family kinases to induce phosphorylation of ZBP1, thus initiating translation. Here, ZBP1 is linked to colorectal cancer.