In this cohort, we also analyzed the levels of PAI1 protein by immunohistochemistry (Figure 1E), defining a high PAI1 protein level in the tumor samples when the score of the stained tumor was higher than 1 on a scale of 0–3 (see Material and Methods) compared with non-tumor samples, and low PAI1 protein level when the score was lower than or equal to 1 [41,42]. This evidence concerns the gene SERPINE1 and neoplasm.