In TCGA dataset, SIRTs expression in BlCa compared to paired NB samples disclosed similar results, with a significant decrease of SIRT1 and SIRT3 expression (MW p < 0.0001 and p = 0.0422, respectively; Figure S1A), and significant increase in SIRT6 and SIRT7 expression in BlCa tissues (MW p < 0.0001 for both; Figure S1B). Here, SIRT3 is linked to bladder transitional cell carcinoma.