An independent association has been demonstrated between NF-κB activation and the upregulation of oncogenic miR-21 and/or downregulation of tumor suppressor miR-34a and miR-451a [18,20,37,38,39], while a cluster of genes and miRNA markers have been implicated in activating NF-κB and contributing to an aggressive phenotype of head and neck cancer [39]. The gene discussed is NFKB1; the disease is neoplasm.