UBR3 and Intellectual disability: In Proband 4, a girl with severe intellectual disability and a cured brain dysembryoplastic neuroepithelial tumor, we identified an inversion that disrupted two genes: UBR3 and TRAF3IP1. The inversion did not create a fusion gene as both genes are transcribed from the forward strand (the orientation of the fused genes is incorrect for a chimeric gene to be created).