Mutations of LRSAM1 (leucine-rich repeat and sterile alpha motif containing 1), an E3 ligase with RING ZINC finger domains and leucine-rich repeats, are associated with cases of early-onset Parkinson’s disease [105] and to Charcot-Marie-Tooth disease [62] (Table 1). The gene discussed is LRSAM1; the disease is Parkinson disease.