Several proteins directly regulating post-translational processing and intracellular trafficking, such as tripartite motif-containing 2 (TRIM2) and RAS-related small GTPase RAB7, are also found to be mutated in Charcot-Marie-Tooth disease, confirming the link between vesicle trafficking and Charcot-Marie-Tooth disorder [61]. This evidence concerns the gene TRIM2 and Charcot-Marie-Tooth disease.