PARKIN, or Parkinson Protein 2 (PARK2), is a RBR-type E3 ubiquitin ligase mutated in autosomal recessive juvenile parkinsonism [51], a form of familial Parkinson’s disease, defined by an onset before 40 years of age and characterized by slow movement and tremor (Table 1). This evidence concerns the gene PRKN and Parkinson disease.