Belenchia et al., in a Randomized Controlled Trial (RCT), evaluated the effects of 6 months oral administration of vitamin D at a dose of 4000 IU/day on inflammatory markers in obese adolescents with vitamin D insufficiency, and the results revealed that the intervention insignificantly improved inflammatory markers including IL-6, TNF-α and hs-CR p [27]. Here, IL6 is linked to vitamin D deficiency.