Although several genes and splicing pathway mutations, as well as cytogenetic changes, have been reported to be associated with MDS, including mutations of RAS, TP53, RUNX1, ASXL1, c-CBL, DNMT3A, TET2, EZH2, U2AF1, U2AF35, ZRSR2, SRSF2, and SF3B [6,7,8,9,10], the genetic changes associated with the pathogenesis of MDS still remain unclear. This evidence concerns the gene RUNX1 and myelodysplastic syndrome.