However, alteration of HLA class I molecule expression [158], increase of cytokines (IL-6, TGFβ) [159,160], as well as the activation of STAT3 or NF-κB [160,161] have been reported as potent immunosuppressive mechanisms involved in HNSCC (Figure 1). This evidence concerns the gene NFKB1 and head and neck squamous cell carcinoma.