Recently, Amin et al., have demonstrated in a clinical study of 36 HNSCC patients, HPV+ patients (n = 16) versus HPV− patients (n = 20), that metformin induces a decrease of LTreg Foxp3+ in the intratumoral compartment, and increases the number of LTCD8+ cells in the stromal compartment, respectively, in both populations. The gene discussed is FOXP3; the disease is head and neck squamous cell carcinoma.