These compounds may be useful candidates to combat diseases caused by higher levels of COX-2 like gout, ankylosing spondylitis, osteoarthritis, rheumatoid arthritis, Alzheimer’s disease, ulcerative colitis, depression, epilepsy, irritable bowel diseases, kidney injury, cancer, asthma, hepatitis, pancreatitis, and atherosclerosis. The gene discussed is PTGS2; the disease is early-onset autosomal dominant Alzheimer disease.