RHOA and melanoma: In microgravity, the formation of focal adhesions (paxillin and vinculin) in BL6-10 melanoma cells was reduced, while FAK was recruited and activated, which led to enhanced apoptosis via FAK/RhoA-regulated mTORC1 and AMPK signaling, together with a reduction of proliferation and metastasis compared with control cells at normal gravity [74,75].