For instance, beyond classic synucleinopathies, α-syn aggregation occurs in ALS, AD, HD and brain ischemia, and α-syn aggregates also co-localize with TDP-43, Aβ and tau, overcoming the clear-cut distinction between degenerative and vascular dementia [23,24,25,26]. Here, MAPT is linked to amyotrophic lateral sclerosis.