In cultured murine-derived neurons, motor neurons, astrocytes and oligodendrocytes, infection with recombinant adenovirus vectors encoding WT and mutant FUS leads to intracellular FUS aggregates formation, which is exacerbated upon co-infection with short hairpin RNAs (shRNAs) for the 26S proteasome regulatory subunit 1 PSMC1 and the autophagy gene ATG5 [181]. Here, PSMC1 is linked to infection.