Since histone deacetylase 3 (HDAC3) is involved in neuronal toxicity, in huntingtin-induced cell death, and immune events, Jia et al. investigated the effects of a selective HDAC3 inhibitor, named RGFP966 ((E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide) in a murine model of HD [60]. This evidence concerns the gene HDAC3 and Huntington disease.