In contrast to the two previous in vivo studies, Cheng et al. demonstrated that microglial autophagy deficiency in mice increased neuroinflammation, determined PD-like symptoms, and enhanced mRNA and protein brain MIF levels in a NLR family pyrin domain containing 3 (NLRP3) inflammasome-dependent manner [52]. This evidence concerns the gene NLRP3 and Parkinson disease.