FOXF2 and breast cancer: With respect to osteomimicry, Wang and coworkers have recently demonstrated the key role of the transcription factor forkhead box F2 (FOXF2), which is physiologically involved in the maintenance of tissue homeostasis and embryo development but has also been shown to activate BMP-4/SMAD1 signaling in BC cells while up-regulating bone-related genes to sustain the bone metastatic process [27].