This is evident from the results obtained in diverse experimental models of inflammation including hepatic ischemia-reperfusion, colitis, atopic dermatitis, in which H4R antagonists (JNJ7777120, JNJ10191584, thioperamide) proved to be efficient anti-inflammatory agents with reduced neutrophil recruitment and release of cytokines [51,52]. This evidence concerns the gene HRH4 and atopic eczema.