Other tumor features also have been reported to be relevant in the development of lymph node metastases, such as the infiltrating pattern of growth of the tumor, “tumor budding” and lymphovascular and perineural invasion [69,70,71,72]; molecular changes, such as loss of N33, STK11 and TP53 [73]; as well as immune alteration, such as HLA-E overexpression [74]. The gene discussed is HLA-E; the disease is neoplasm.