Univariate analysis revealed that the disease stage (IV vs. II/III), the detection of microbial DNA encoding for 16S rRNA, glutamine synthase of B. fragilis, and 5.8S rRNA were significantly associated with a shorter PFS; and tumor location (right vs. left colon), disease stage (IV vs. II/III), the detection of microbial DNA encoding for 16S rRNA, β-galactosidase of E. coli, glutamine synthase of B. fragilis, and 5.8S rRNA were significantly associated with shorter OS (Table 4). This evidence concerns the gene GLUL and neoplasm.