To explore the functional role of PRDM8 in VN-MCC, we performed CRISPR-mediated gene silencing of PRDM8 in MCC13 and MCC26 cell lines (two VN-MCC cell lines) and validated CRISPR efficiency at gene and RNA expression level (Figure 2C,D). Here, PRDM8 is linked to Merkel cell skin cancer.