GRN and amyotrophic lateral sclerosis: Major genes that have been reported in multiple subsets of ALS or FTD include superoxide dismutase 1 (SOD1), TAR DNA binding protein (TARDBP coding for TDP-43 protein), fused in sarcoma (FUS), chromosome 9 open reading frame 72 (C9ORF72), microtubule-associated protein tau (MAPT), progranulin (PGRN), and valosin containing protein (VCP).