Moreover, circulating SELENOP levels correlated with HOMA-IR and were more than 3-fold higher in patients with obesity (52.3 ± 39.1 vs. 14.5 ± 12.8 μg/mL, p < 0.001), whereas SAT SELENOP mRNA expression was significantly associated with BMI [101]. This evidence concerns the gene SELENOP and obesity due to melanocortin 4 receptor deficiency.