SEPHS2 and obesity due to melanocortin 4 receptor deficiency: A genome-wide association study in high fat and cholesterol diet-fed mice presented a significant inverse correlation (r = −0.68; p < 0.001) between epididymal adipose tissue selenophosphate synthetase 2 gene (Sephs2) expression and BF% [237], being indicative of the potential role of impaired Sephs2 in obesity pathogenesis.