APOE and Alzheimer disease: For example, overexpression of IL-10 has been shown to increase amyloid-β (aβ) accumulation, worsen memory, and increase ApoE expression, especially in the plaque-associated insoluble cellular fraction, while microglial aβ phagocytosis was found to be reduced in amyloid precursor protein (APP) mice, a model of Alzheimer’s disease [43].