In patients, this mutation could affect the regulation of GADD45A, GADD45B, GADD45G, and RHOB at the post-transcriptional level, resulting in upregulated expression of encoded pro-apoptotic factors, thereby causing increased apoptosis of germ cells and finally, the absence of germ cells from seminiferous tubules and infertility. Here, GADD45A is linked to Infertility.