The second model proposes that capsid undergoes structural changes in the cytoplasm resulting in capsid rupture where a portion of capsid remains intact until disassembly is completed at the nuclear pore, this model agrees with the idea that during trafficking along microtubules, cytoplasmic dynein and kinesin 1, particularly Kif5B, are required for this process as the genetic inhibition of DHC and Kif5B by siRNA, or pharmacological inhibition of dynein function, delayed uncoating, and reduced HIV-1 infection [33]. This evidence concerns the gene KIF5B and HIV-1 infection.