Moreover, they have shown that the KO of BicD2 leads to the expression of interferon stimulated gene (ISG) upon HIV-1 infection, suggesting that in the absence of BicD2, viral DNA accumulates in the cytosol leading to an antiviral response, while in presence of BicD2, the PIC will travel rapidly towards the nucleus along microtubules, and avoid detection by the cellular innate immune machinery. Here, BICD2 is linked to HIV-1 infection.