In saliva, Delmonico et al. [14] identified differences in alpha-2-macroglobulin, ceruplasmin, haptoglobin, hemopexin and vitamin D-binding, among others, in women with impalpable breast cancer in comparison to healthy women; and Giri et al. [15] identified 166 proteins with different expression in saliva of women with breast cancer in comparison to healthy controls [15]. This evidence concerns the gene A2M and breast carcinoma.