In recent years, proteins of the GRAF family have attracted attention because they are mutated in cancer (Li et al., 2017; Aissani et al., 2015; Bozóky et al., 2013; Qian et al., 2010) and have been associated with neuropsychiatric diseases (Barresi et al., 2010; Jarius and Wildemann, 2015; Dahm et al., 2014), but little mechanistic information has been published. Here, ARHGAP26 is linked to cancer.