SYNGAP1 and central nervous system cancer: Excluding the syndromes associated with mutations in the MECP2 and SYNGAP1 genes, the occurrence of STE is more common in the second decade of life and a male predisposition exists in both structural and genetic cases.9, 10, 11, 15, 30 The only 2 human patients described with gliomas were aged 14 and 44 years.23, 24 In contrast to what occurs in humans, we identified more female than male dogs and the age of onset (excluding the 1 case of structural STE) was >12 months and within the range expected for dogs with IE.31