Given that SQSTM1-NUP214 was identified in a leukemia with upregulation of HOXA genes [27], we examined the effect of SQSTM1-NUP214 on transcript levels of Hoxa and Meis1, an essential Hox cofactor, in the bone marrow blasts of murine leukemias induced by SQSTM1-NUP214. The gene discussed is NUP214; the disease is leukemia.