Compared to levels in Hoxa9/Meis1 leukemias, endogenous Hoxa9 and Hoxa10 were considerably elevated in SQSTM1-NUP214 leukemias (Fig 3A), whereas the levels of Hoxa3, Hoxa5, Hoxa7, Hoxa11 and Meis1 were comparable in Hoxa9/Meis1 and SQSTM1-NUP214 leukemias. Here, SQSTM1 is linked to leukemia.