SQSTM1 and Splenomegaly: The SQSTM1-NUP214 leukemias were characterized by splenomegaly (mean spleen weight ± SD: 0.30 ± 0.13 g, S1 Data), variable leukocytosis, and invasion of the bone marrow with SQSTM1-NUP214 expressing blasts, as evidenced by GFP-positive cells representing at least 95% of the bone marrow cells in terminally diseased mice.