CLC and Dent disease: Mutations in at least five of the human CLC genes lead to genetically inherited disorders of muscle (Thomsen and Becker type Myotonia congenita), kidney (Bartter Syndrome Type III and IV, Dent’s disease), bone (Osteopetrosis) and central nervous system (neuronal ceroid lipofuscinosis, retinal degeneration, deafness, syndromic intellectual disability, seizure disorders), highlighting the fundamental roles of CLC channels and transporters in human physiology (Jentsch, 2008; Stauber et al., 2012; Hu et al., 2016; Jentsch and Pusch, 2018; Palmer et al., 2018).