Patients who have Rett Syndrome exhibit respiratory impairments and seizure (Chahrour and Zoghbi, 2007), and these phenotypes are replicated in mouse models following deletion of Mecp2 from all GABAergic cells (Chao et al., 2010; Ito-Ishida et al., 2015). Here, MECP2 is linked to atypical Rett syndrome.