MECP2 and Anxiety: On the basis of previous characterizations of the Mecp2 model (Chahrour and Zoghbi, 2007; Samaco et al., 2008; Chao et al., 2010; He et al., 2014; Ito-Ishida et al., 2015), we examined interneuron contributions to several major categories of neural dysregulation: mortality and seizure, cortical activity patterns, anxiety and repetitive behaviors, and social behavior.