In a recent influenza vaccine study, we found that vaccine non-responders were polarized towards an inflammatory Th1/Th17 phenotype with predominant production of inflammatory cytokine TNF and Tfh antagonistic cytokine IL-2, while in responders, pTfh cells showed a Th2 phenotype with ICOS upregulation and IL-21 production (Pallikkuth et al., 2019). The gene discussed is TNF; the disease is influenza.