Upon comparison of FCCP versus Poly(I:C) or LPS effects, and comparing also Lonp1+/− versus Tfam+/− and ClpP−/− effects upon the expression of Rnf213 and other inflammatory factors, it appears that respiratory failure is less potent for the induction of Rnf213 than the dysregulation of mitochondrial nucleotides as an immunological trigger. The gene discussed is RNF213; the disease is respiratory failure.