TFAM and bacterial infectious disease: The data now reported confirm that also the RNF213 protein abundance is upregulated > 4-fold in ClpP−/− brain, while Lonp1 as the other AAA+ ATPase/peptidase in the mitochondrial matrix and Tfam as the main mitochondrial transcription factor show unchanged levels (Fig. 1), indicating a quite selective effect of ClpP for Rnf213. This ClpP-genotype-dependent impact on Rnf213 now was documented also for immune cells, namely BMDM upon challenge with LPS rather than Pam3CSK4, both of them being simulators of bacterial infection (Fig. S1).