TREX1 and Aicardi-Goutières syndrome: There are other well-known vasculopathies that are caused by impaired nucleotide processing, such as Aicardi-Goutières syndrome that is caused by mutations in the ribonuclease RNASEH2, the exonuclease TREX1, or the deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [73–75], or such as SLE that is triggered by autoimmune responses to toxic DNA or also to mtRNA [76–79].