APP and Alzheimer disease: Recently, the impact of APP on different human diseases such as neurodevelopmental and neurodegenerative disorders including rare diseases such as autism [5]–[7], FXS [6]–[8], ALS [9], MS [10]–[14], LND [15]–[20]; common and complex disorders such as AD [21]–[31]; metabolic disorders such as diabetes [32]–[34]; and also cancer [35]–[46] has been reported.