It is well reported that human postmortem tissue in major depressive disorders (MDD) have shown alterations in the expression of mRNA and protein for astrocyte markers such as GFAP, Cx40, Cx43, AQP4, S100β and glutamatergic markers including GLT-1, GLAST, and GS [53]. This evidence concerns the gene SLC1A2 and major depressive disorder.