It is well reported that human postmortem tissue in major depressive disorders (MDD) have shown alterations in the expression of mRNA and protein for astrocyte markers such as GFAP, Cx40, Cx43, AQP4, S100β and glutamatergic markers including GLT-1, GLAST, and GS [53]. The gene discussed is GJA1; the disease is major depressive disorder.