GFAP and Cushing syndrome due to macronodular adrenal hyperplasia: Alterations in the GC signaling are thought to contribute to disorders like Major Depression (MD) [13], Alzheimer's disease [14], and Cushing's syndrome [15], etc. A recent study on MD, showed that reduced levels of glial fibrillary acidic protein (GFAP) immunoreactive astrocytes [16] while the release of GCs in response to chronic stress leading to MD has been widely reported [17].