Primary ovarian insufficiency (POI), also known as premature ovarian failure prior to 2008, is defined as the presence of reduced ovarian functions in women younger than 40 years, characterized by oligo- or amenorrhea, sub- or infertility, loss of residual follicles in the gonads, low estradiol levels, and high (menopausal) follicle-stimulating hormone (FSH) levels(1,2). This evidence concerns the gene BRD2 and primary ovarian failure.