On the contrary, PFKFB3 expression is increased in synovial tissue and fibroblast-like synoviocytes in RA patients compared to osteoarthritis patients.[55] Blockade of PFKFB3 pathway resulted in reduced expression of IL-6, IL-8, CCL-2, CXCL-10 and decreased proliferation, migration and invasion of FLS in RA patients [55]. This evidence concerns the gene IL6 and rheumatoid arthritis.