Toll like receptor-9, and cyclic guanosine monophosphate—AMP (2′3′cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) are crucial DNA sensing pathways implicated in the pathogenesis of SLE via IFN production (Figure 3) [97,98]. This evidence concerns the gene CGAS and systemic lupus erythematosus.