The phosphatidylinositol 3-kinase (PI3K)/Akt/ mTOR pathway plays a critical role in the development of PCa and progression to castration-resistant PCa: components of the PI3K/Akt/mTOR pathway are altered in 42% of primary and 100% of metastatic PCa cases [10]. This evidence concerns the gene AKT1 and posterior cortical atrophy.