Here we have utilized FMT imaging to demonstrate the biodistribution and tumor targeting of P-cadherin LP-DART; the pharmacodynamic effect, i.e., the trafficking of T cells to the tumor microenvironment; the exposure profile of P-cadherin LP-DART, its scDb form (with no Fc domain) and the differences between administering P-cadherin LP-DART by subcutaneous vs intravenous route. This evidence concerns the gene CDH3 and neoplasm.