TGFB1 and breast cancer: The DEAR1 gene in breast cancer has been considered a predictor of local recurrence-free survival in early-onset breast cancer; it regulates polarity and tissue architecture1 and is a master regulator of transforming growth factor β (TGF-β)-driven epithelial-mesenchymal transition (EMT).3 In breast cancer, DEAR1 is downregulated in ductal carcinoma in situ lesions and infiltrating ductal carcinoma.1