Although the impact of high-risk mutations is important, they account for less than 25% of the cases of breast cancer predisposition; other risk factors can be explained by the addition of multiple common variants, known as low-penetrance variants in the polygenic model.8, , -11 Analyses performed on different populations allow discovering causal factors.12 The association of Tag SNPs rs584298, rs2927970, rs59983645, and rs599167 in DEAR1 with risk of breast cancer was analyzed in the total of cases and controls in women from the Colombian population by genotyping. The gene discussed is TRIM62; the disease is breast carcinoma.