The DEAR1 gene located in the region 1p35.1 encodes for a member of the tripartite motif (TRIM) protein, one of the subfamilies of the RING type E3 ubiquitin ligases, which is associated with the development of breast cancer and invasion.3 Functional cell line mutational analysis provides evidence that DEAR1 is a key regulator of acinar morphogenesis in the mammary gland and an independent predictor of local recurrence-free survival. The gene discussed is TRIM5; the disease is breast cancer.