TMC4 and breast cancer: TMC4 encodes a transmembrane channel protein52; while its expression was upregulated in tumor-versus-adjacent tissue in our dataset as well as TCGA, other studies reported its downregulation in high-metastatic breast cancer cell lines compared to their low metastatic counterparts53 as well as breast-cancer cells compared to normal breast epithelium54, and its increased expression in tumors was associated with better survival of breast cancer patients55.