GPX4 and Alzheimer disease: In neurodegeneration [43], a number of ferroptosis features are commonly reported, in particular depletion of glutathione, accumulation of lipid peroxidation products, excess extracellular glutamate, decreased cortical GPX4, increased lipoxygenase (LOX) activity, protection from lipophilic antioxidant vitamin E (in AD), protection from iron chelators [44], and protection from pioglitazone, an ACSL4 inhibitor [45].