Moreover, among the genes that showed a decreased expression in the transgenic spleens we found (i) transcripts down-regulated in post- germinal center (GC) BCL6 dependent B cell lymphomas when compared to MYC driven pre-GC lymphomas (Cnot6l, Sh3kbp1)43,44, (ii) genes repressed by BLIMP1 (Stat6, Zfp36l1)45,46; (iii) genes present in the GC B-cell type (GCB) DLBCL signature (Dtx1,Cux1, Sh3pxd2a, Klhl6)47–49 (Fig. 6). The gene discussed is PRDM1; the disease is lymphoma.